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Publications

Independent Publications:

* = undergrad co-author; ^ = equal contribution​

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  • Schuelke-Sanchez, A.E.; Yennawar, Y.H.; Weinert, E.E. (2024) Oxygen-selective regulation of cyclic di-GMP synthesis by a globin coupled sensor with a shortened linking domain modulates Shewanella sp. ANA-3 biofilm. J. Inorg. Biochem. 252, 112482. DOI: 10.1016/j.jinorgbio.2024.112482

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  • Marotta, N.J.; Weinert, E.E. (2023) Insights into the metabolism, signaling, and physiological effects of 2’,3’-cyclic nucleotide monophosphates in bacteria. Crit. Rev. Biochem. Mol. Biol. DOI: 10.1080/10409238.2023.2290473

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  • Hoque, N.J.; Weinert, E.E. (2023) Control of bacterial second messenger signaling and motility by heme-based direct oxygen-sensing proteins. Curr. Opin. Microbiol. 76, 102396. DOI: 10.1016/j.mib.2023.102396

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  • Fekete, F.J.; Marotta, N.J.; Liu, X.; Weinert, E.E. (2023) An O2-Sensing Diguanylate Cyclase Broadly Affects the Aerobic Transcriptome in the Phytopathogen Pectobacterium carotovorum. Front. Microbiol. DOI: 10.3389/fmicb.2023.1134742

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  • Hoque, N.J.; Helm, M.P.; Weinert, E.E. (2023) In Vitro Measurement of Gas-Dependent and Redox-Sensitive Diguanylate Cyclase Activity. Methods Mol. Biol. 2648, 75-86. DOI: 10.1007/978-1-0716-3080-8_6

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  • Patterson, D. C.; Weinert, E.E. (2023) Spectrophotometric Method for the Quantification and Kinetic Evaluation of In Vitro c-di-GMP Hydrolysis in the Presence and Absence of Oxygen. Methods Mol. Biol. 2648, 87-98. DOI: 10.1007/978-1-0716-3080-8_7

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  • Kurasz, J.E.; Crawford, M.C.; Porwollik, S.; Gregory, O.; Tadlock, K.R.; Balding, E.C.; Weinert, E.E.; McClelland, M.; Karls, A.C. (2023) Strain-Specific Gifsy-1 Prophage Genes Are Determinants for Expression of the RNA Repair Operon during the SOS Response in Salmonella enterica Serovar Typhimurium. J. Bacteriol. 205, e00262-22. DOI: 10.1128/jb.00262-22

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  • Chauhan, S.S.; Weinert, E.E. (2023) Generation of nucleotide-linked resins for identification of novel binding proteins. Methods Enzymol. 679, 323-330. DOI: 10.1016/bs.mie.2022.08.052

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  • ​Rizk, A.A; Komazin, G.; Maybin, M.; Hoque, N.J.; Weinert, E.E.; Meredith, T.C. (2023) The Extracellular Electron Transport Pathway Reduces Copper for Sensing by the CopRS Two-Component System under Anaerobic Conditions in Listeria monocytogenes. J. Bacteriol. 205, e00391-22. DOI: 10.1128/jb.00391-22

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  • Chauhan, S.S.; Marotta, N.K.; Karls, A.C.; Weinert, E.E. (2022) Binding of 2',3'-Cyclic Nucleotide Monophosphates to Bacterial Ribosomes Inhibits Translation. ACS Cent. Sci. DOI: 10.1021/acscentsci.2c00681

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  • Duggal, Y.;^ Kurasz, J.E.^; Fontaine, B.M.^; Marotta, N.J.; Chauhan, S.S.; Karls, A.C.; Weinert, E.E. (2022) Cellular Effects of 2’,3’-Cyclic Nucleotide Monophosphates in Gram-Negative Bacteria. J. Bacteriol. 204, e00208-21. DOI: 10.1128/JB.00208-21

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  • Patterson, D.C.; Liu, Y.; Das, D.; Yennawar, N.H.; Armache, J.-P.; Kincaid, J.R.; Weinert, E.E. (2021) Heme Edge Residues Modulate Signal Transduction Within a Bifunctional Homo-Dimeric Sensor Protein. Biochemistry. 60, 3801-3812. DOI: 10.1021/acs.biochem.1c00581

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  • Patterson, D.C.; Perez Ruiz, M.; Yoon, H.*; Walker, J.A.; Armache, J.-P.; Yennawar, N.H.; Weinert, E.E. (2021) Differential Ligand-Selective Control of Opposing Enzymatic Activities Within a Bifunctional c-di-GMP Enzyme. Proc. Natl. Acad. Sci. USA. 118, e2100657118. DOI: 10.1073/pnas.2100657118

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  • Duggal, Y.^; Fontaine, B.M.^; Dailey, D.M.*; Ning, G.; Weinert, E.E. (2020) RNase I Modulates Escherichia coli Motility, Metabolism, and Resistance. ACS Chem. Biol. 15, 1996-2004. DOI: 10.1021/acschembio.0c00390

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  • Fontaine, B.M.; Duggal, Y.; Weinert, E.E. (2020) 2',3'-Cyclic Mononucleotide Metabolism and Possible Role in Bacterial Physiology. In Microbial Cyclic Di-Nucleotide Signaling. Chou, S.-H.; Guiliani, N.; Lee, V.T.; Romling, U.; Eds. Ch. 36, 627-637.

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  • Walker, J.A.; Wu, Y.*; Potter, J.R.; Weinert, E.E. (2020) pi-Helix Controls Activity of Oxygen-Sensing Diguanylate Cyclases. Biosci. Rep. 40, BSR20193602. DOI: 10.1042/BSR20193602​

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  • Fontaine, B.M.^; Duggal, Y.^; Weinert, E.E. (2018) Exploring the Links between Nucleotide Signaling and Quorum Sensing Pathways in Regulating Bacterial Virulence. ACS Infect. Dis. 14, 1645-1655. DOI: 10.1021/acsinfecdis.8b00255

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  • Rivera, S.^; Young, P.G.*^; Hoffer, E.D.; Vansuch, G.E.; Metzler, C.L.*; Dunham, C.M.; Weinert, E.E. (2018) Structural Insights into Oxygen-Dependent Signal Transduction within Globin Coupled Sensors. Inorg. Chem. 57, 14386-14395. DOI: 10.1021/acs.inorgchem.8b02584

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  • Fontaine, B.M.; Martin, K.S.; Garcia-Rodriguez, J.M.*; Jung, C.*; Briggs, L.*; Southwell, J.E.*; Jia, X.; Weinert, E.E. (2018) RNase I Regulates E. coli 2′,3′-Cyclic Nucleotide Monophosphate Levels and Biofilm Formation. Biochem. J. 475, 1491-1506. DOI: 10.1042/BCJ20170906

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  • Walker, J.A.^; Rivera, S.^; Weinert, E.E. (2017) Mechanism and Role of Globin Coupled Sensor Signaling. Adv. Microb. Physiol. 71, 133-169. DOI: 10.1016/bs.ampbs.2017.05.003

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  • Burns, J.L.; Jariwala, P.B.; Rivera, S.; Fontaine, B.M.; Briggs, L.; Weinert, E.E. (2017) Oxygen-Dependent Globin Coupled Sensor Signaling Modulates Motility and Virulence of the Plant Pathogen Pectobacterium carotovorum. ACS Chem. Biol. 12, 2070-2077. DOI: 10.1021/acschembio.7b00380

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  • Fontaine, B.M.; Nelson, K.; Lyles, J.T.; Jariwala, J.B.*; Garcia-Rodriguez, J.M.*; Quave, C.L.; Weinert, E.E. (2017) Identification of Ellagic Acid Rhamnoside as a Bioactive Component of a Complex Natural Product Extract with Anti-biofilm Activity. Front. Microbiol. 8. 496. DOI: 10.3389/fmicb.2017.00496

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  • Kim, Y.J.*; Kalusz, S.; Mehta, A.; Weinert, E.E.; Rivera, S.; Van Meir, E.G. Purifying Properly Folded Cysteine-Rich Zinc Finger Containing Recombinant Proteins for Structural Drug Targeting Studies: the CH1 Domain of p300 as a Case Example. Bio-Protocol. 2017, 17, DOI: 10.21769/BioProtoc.2537

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  • Burns, J.L.; Rivera, S.; Deer, D.D.; Joynt, S.C.; Dvorak, D.*; Weinert, E.E. (2016) Oxygen and c-di-GMP Binding Control Oligomerization State Equilibria of Diguanylate Cyclase-Containing Globin Coupled Sensors. Biochemistry. 55, 6642-6651. DOI: 10.1021/acs.biochem.6b00526

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  • Rivera, S.; Burns, J.L.; Vansuch, G.E.; Chica, B.; Weinert, E.E. (2016) Globin Domain Interactions Control Heme Pocket Conformation and Oligomerization of Globin Coupled sensors. J. Inorg. Biochem. 164, 70-76. DOI: 10.1016/j.jinorgbio.2016.08.016

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  • Jia, X.; Wang, J.-b.; Rivera, S.; Duong, D.; Weinert, E.E. (2016) An O2-sensing stressosome from a Gram-negative bacterium. Nature Commun. 7, 12381. DOI: 10.1038/ncomms12381​

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  • Jia, X.; Fontaine, B.M.; Strobel, F.; Weinert, E.E. (2014) A Facile and Sensitive Method for Quantification of Cyclic Nucleotide Monophosphates in Mammalian Organs: Basal Levels of Eight cNMPs and Identification of cIMP. Biomolecules. 4, 1070-1092. DOI: 10.3390/biom4041070

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  • Burns, J.L., Deer, D.D., Weinert, E.E. (2014) Oligomeric State Affects Oxygen Dissociation and Diguanylate Cyclase Activity of Globin Coupled Sensors. Mol. BioSyst. 10, 2823-2826. DOI: 10.1039/c4mb00366g

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Publications From Previous Work:

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  • Weinert, E.E., Phillips-Piro, C.M., Marletta, M.A. (2013) Porphyrin pi-Stacking in a Heme Protein Scaffold Tunes Gas Ligand Affinity. J. Inorg. Biochem. 127, 7-12.

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  • Whited, C.A., Warren, J.J., Lavoie, K.D., Weinert, E.E., Agapie, T., Winkler J.R., Gray, H.B. (2012) Gating NO Release from Nitric Oxide Synthase. J. Am. Chem. Soc., 134, 27-30.

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  • Weinert, E.E., Phillips-Piro, C.M., Tran, R., Mathies, R.A., Marletta, M.A. (2011) Controlling Conformational Flexibility of an O2-Binding H-NOX Domain. Biochemistry, 50, 6832-40.

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  • Tran, R., Weinert, E.E., Boon, E.M., Mathies, R.A., Marletta, M.A. (2011) Determinants of Heme-CO Vibrational Modes in the H-NOX Family. Biochemistry, 50, 6519-30.

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  • McCrane, M.P., Weinert, E.E., Lin, Y., Mazzola, E.P., Lam, Y.-F., Rokita, S.E. (2011) Trapping a Labile Adduct Formed between an ortho-Quinone Methide and 2′-Deoxycytidine. Org. Lett., 13, 1186-1189.

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  • Weinert, E.E. , Marletta, M.A. (2011) Heme Sensor Proteins. In Handbook of Porphyrin Science. Kadish, K.M., Smith, K.M., Guilard, R., Eds.; 5, 123-157.

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  • Weinert, E.E., Plate, L., Whited, C.A., Olea, C., Jr., Marletta, M.A. (2010) Determinants of Ligand Affinity and Heme Reactivity in H-NOX Domains. Angew. Chem., Int. Ed., 49, 720-723.

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  • Weinert, E.E., Dondi, R., Colloredo-Melz, S., Frankenfield, K.N., Mitchell, C.H., Freccero, M., Rokita, S.E. (2006) Substituents on Quinone Methides Strongly Modulate Formation and Stability of their Nucleophilic Adducts.  J. Am. Chem. Soc., 128, 11940-11947.

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  • Weinert, E.E., Frankenfield, K.N., Rokita, S.E. (2006) Time-Dependent Evolution of Adducts Formed between Deoxynucleosides and a Model Quinone Methide. Chem. Res. Toxicol., 18, 1364-1370.

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  • Xu, R.X.; Lambert, M.H.; Wisely, B.B.; Warren, E.N.; Weinert, E.E.; Waitt, G.M.; Williams, J.D.; Collins, J.L.; Moore, L.B.; Willson, T.M.; Moore, J.T. (2004) A Structural Basis for Constitutive Activity in the Human CAR/RXRα Heterodimer. Mol. Cell., 16, 919-928.

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  • Liu, Y.; Kempf, V.R.; Nofsinger, J.B.; Weinert, E.E.; Rudnicki, M.; Wakamatsu, K.; Ito, S.; Simon, J.D. (2003) Comparison of the Structural and Physical Properties of Human Hair Eumelanin Following Enzymatic or Acid/Base Extraction. Pigment Cell Res., 16, 355-365.

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  • Nofsinger, J.B.; Weinert, E.E.; Simon, J.D. (2002) Establishing Structure/Function Relationships for Eulmelanin. Biopolymers, 67, 302-305.

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  • Sutherland, B.M.; Bennett, P.V.; Weinert, E.; Sidorkinda, O.; Laval, J. (2001) Frequencies and Relative Levels of Clustered Damages in DNA Exposed to Gamma Rays in Radioquenching vs. Nonradioquenching Conditions. Environ. Mol. Mutagenesis., 38, 159-165. 

 

Patents:

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Cary, S. P. L.; Boon, E.M.; Weinert, E.E.; Winger, J.A.; Marletta, M.A. 2007,  PCT Int. Appl. WO  2007139791.

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